1i30

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[[Image:1i30.gif|left|200px]]
[[Image:1i30.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i30 |SIZE=350|CAPTION= <scene name='initialview01'>1i30</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1i30", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=826:1,3,4,9-TETRAHYDRO-2-(HYDROXYBENZOYL)-9-[(4-HYDROXYPHENYL)METHYL]-6-METHOXY-2H-PYRIDO[3,4-B]INDOLE'>826</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1i30| PDB=1i30 | SCENE= }}
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|RELATEDENTRY=[[1c14|1C14]], [[1i2z|1I2Z]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i30 OCA], [http://www.ebi.ac.uk/pdbsum/1i30 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i30 RCSB]</span>
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}}
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'''E. COLI ENOYL REDUCTASE +NAD+SB385826'''
'''E. COLI ENOYL REDUCTASE +NAD+SB385826'''
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==Reference==
==Reference==
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11514139 11514139]
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11514139 11514139]
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[[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
 
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Qiu, X.]]
[[Category: Qiu, X.]]
[[Category: Seefeld, M A.]]
[[Category: Seefeld, M A.]]
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[[Category: acp]]
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[[Category: Acp]]
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[[Category: antibiotic]]
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[[Category: Antibiotic]]
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[[Category: enoyl reductase]]
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[[Category: Enoyl reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:30:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:13:52 2008''
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Revision as of 16:30, 2 May 2008

Image:1i30.gif

Template:STRUCTURE 1i30

E. COLI ENOYL REDUCTASE +NAD+SB385826


Overview

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.

About this Structure

1I30 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:11514139 Page seeded by OCA on Fri May 2 19:30:38 2008

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