4bhx

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<StructureSection load='4bhx' size='340' side='right'caption='[[4bhx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='4bhx' size='340' side='right'caption='[[4bhx]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bhx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BHX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bhx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BHX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhx OCA], [http://pdbe.org/4bhx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bhx RCSB], [http://www.ebi.ac.uk/pdbsum/4bhx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bhx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bhx OCA], [https://pdbe.org/4bhx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bhx RCSB], [https://www.ebi.ac.uk/pdbsum/4bhx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bhx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PEG3_HUMAN PEG3_HUMAN]] Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.<ref>PMID:11260267</ref>
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[[https://www.uniprot.org/uniprot/PEG3_HUMAN PEG3_HUMAN]] Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells.<ref>PMID:11260267</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==

Revision as of 07:14, 31 August 2022

Crystal structure of the SCAN domain from human paternally expressed gene 3 protein

PDB ID 4bhx

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