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4bik

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<StructureSection load='4bik' size='340' side='right'caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
<StructureSection load='4bik' size='340' side='right'caption='[[4bik]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27335 Atcc 27335] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_27335 Atcc 27335] and [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BIK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [http://pdbe.org/4bik PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [http://www.ebi.ac.uk/pdbsum/4bik PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bik ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bik OCA], [https://pdbe.org/4bik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bik RCSB], [https://www.ebi.ac.uk/pdbsum/4bik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bik ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[http://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
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[[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:[https://omim.org/entry/612300 612300]].<ref>PMID:1382994</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
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[[https://www.uniprot.org/uniprot/CD59_HUMAN CD59_HUMAN]] Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[CD59|CD59]]
*[[CD59|CD59]]
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*[[Cytolysin 3D structures|Cytolysin 3D structures]]
== References ==
== References ==
<references/>
<references/>

Revision as of 07:15, 31 August 2022

Structure of a disulfide locked mutant of Intermedilysin with human CD59

PDB ID 4bik

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