1i3o

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[[Image:1i3o.gif|left|200px]]
[[Image:1i3o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i3o |SIZE=350|CAPTION= <scene name='initialview01'>1i3o</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1i3o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= I39005 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), U32974 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1i3o| PDB=1i3o | SCENE= }}
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|RELATEDENTRY=[[1c9q|1C9Q]], [[1pau|1PAU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i3o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i3o OCA], [http://www.ebi.ac.uk/pdbsum/1i3o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i3o RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3'''
'''CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3'''
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[[Category: Sun, C.]]
[[Category: Sun, C.]]
[[Category: Zhou, Q.]]
[[Category: Zhou, Q.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: caspase]]
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[[Category: Caspase]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: iap]]
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[[Category: Iap]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:10 2008''
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Revision as of 16:32, 2 May 2008

Image:1i3o.gif

Template:STRUCTURE 1i3o

CRYSTAL STRUCTURE OF THE COMPLEX OF XIAP-BIR2 AND CASPASE 3


Overview

The molecular mechanism(s) that regulate apoptosis by caspase inhibition remain poorly understood. The main endogenous inhibitors are members of the IAP family and are exemplified by XIAP, which regulates the initiator caspase-9, and the executioner caspases-3 and -7. We report the crystal structure of the second BIR domain of XIAP (BIR2) in complex with caspase-3, at a resolution of 2.7 A, revealing the structural basis for inhibition. The inhibitor makes limited contacts through its BIR domain to the surface of the enzyme, and most contacts to caspase-3 originate from the N-terminal extension. This lies across the substrate binding cleft, but in reverse orientation compared to substrate binding. The mechanism of inhibition is due to a steric blockade prohibitive of substrate binding, and is distinct from the mechanism utilized by synthetic substrate analog inhibitors.

About this Structure

1I3O is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of caspase-3 by XIAP., Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS, Cell. 2001 Mar 9;104(5):791-800. PMID:11257232 Page seeded by OCA on Fri May 2 19:32:05 2008

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