1i3r

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[[Image:1i3r.jpg|left|200px]]
[[Image:1i3r.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1i3r |SIZE=350|CAPTION= <scene name='initialview01'>1i3r</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1i3r", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= IEK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1i3r| PDB=1i3r | SCENE= }}
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|RELATEDENTRY=[[1iea|1IEA]], [[1ieb|1IEB]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i3r OCA], [http://www.ebi.ac.uk/pdbsum/1i3r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i3r RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE'''
'''CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE'''
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[[Category: Kappler, J W.]]
[[Category: Kappler, J W.]]
[[Category: Wilson, N.]]
[[Category: Wilson, N.]]
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[[Category: mhc classii]]
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[[Category: Mhc classii]]
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[[Category: peptide]]
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[[Category: Peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:32:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:10 2008''
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Revision as of 16:32, 2 May 2008

Image:1i3r.jpg

Template:STRUCTURE 1i3r

CRYSTAL STRUCTURE OF A MUTANT IEK CLASS II MHC MOLECULE


Overview

IE/DR MHC class II molecules have an extensive H-bonding network under the bound peptide. In IE(k), two alpha chain acidic amino acids in the core of this network were mutated to amides. At low pH, the mutant molecule exchanged peptide much more rapidly than the wild-type. The crystal structure of the mutant IE(k) revealed the loss of a single buried water molecule and a reorganization of the predicted H-bonding network. We suggest that these mutations enhance the transition of MHC class II to an open conformation at low pH allowing the bound peptide to escape. In wild-type IE(k), the need to protonate these amino acids also may be a bottleneck in the return to a closed conformation after peptide binding.

About this Structure

1I3R is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Mutations changing the kinetics of class II MHC peptide exchange., Wilson N, Fremont D, Marrack P, Kappler J, Immunity. 2001 May;14(5):513-22. PMID:11371354 Page seeded by OCA on Fri May 2 19:32:15 2008

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