1i47

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[[Image:1i47.gif|left|200px]]
[[Image:1i47.gif|left|200px]]
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{{Structure
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|PDB= 1i47 |SIZE=350|CAPTION= <scene name='initialview01'>1i47</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1i47", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=C45:N4-METHOXY-2&#39;-DEOXY-CYTIDINE-5&#39;-MONOPHOSPHATE'>C45</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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{{STRUCTURE_1i47| PDB=1i47 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i47 OCA], [http://www.ebi.ac.uk/pdbsum/1i47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i47 RCSB]</span>
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'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA'''
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA'''
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==About this Structure==
==About this Structure==
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1I47 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA].
==Reference==
==Reference==
Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex., Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A, J Biochem. 2001 Jul;130(1):9-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11432773 11432773]
Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex., Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A, J Biochem. 2001 Jul;130(1):9-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11432773 11432773]
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[[Category: Protein complex]]
 
[[Category: Chatake, T.]]
[[Category: Chatake, T.]]
[[Category: Hikima, T.]]
[[Category: Hikima, T.]]
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[[Category: Tsunoda, M.]]
[[Category: Tsunoda, M.]]
[[Category: Ueno, Y.]]
[[Category: Ueno, Y.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: damaged dna]]
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[[Category: Damaged dna]]
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[[Category: deoxyribonucleic acid]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: double helix]]
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[[Category: Double helix]]
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[[Category: n4-methoxycytosine]]
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[[Category: N4-methoxycytosine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:33:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:26 2008''
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Revision as of 16:33, 2 May 2008

Image:1i47.gif

Template:STRUCTURE 1i47

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA


Overview

To investigate the mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with the sequence d(CGCGAATTmo(4)CGCG), where mo(4)C is 2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined. Two dodecamers form a B-form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms.

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex., Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A, J Biochem. 2001 Jul;130(1):9-12. PMID:11432773 Page seeded by OCA on Fri May 2 19:33:09 2008

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