1i4f

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[[Image:1i4f.gif|left|200px]]
[[Image:1i4f.gif|left|200px]]
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{{Structure
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|PDB= 1i4f |SIZE=350|CAPTION= <scene name='initialview01'>1i4f</scene>, resolution 1.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1i4f", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=1PG:2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL'>1PG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= HLA-A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1i4f| PDB=1i4f | SCENE= }}
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|RELATEDENTRY=[[1qew|1qew]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i4f OCA], [http://www.ebi.ac.uk/pdbsum/1i4f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i4f RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX'''
'''CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX'''
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[[Category: Stroobant, V.]]
[[Category: Stroobant, V.]]
[[Category: Ziegler, A.]]
[[Category: Ziegler, A.]]
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[[Category: human leukocyte antigen]]
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[[Category: Human leukocyte antigen]]
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[[Category: major histocompatibility complex]]
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[[Category: Major histocompatibility complex]]
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[[Category: melanoma-associated antigen]]
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[[Category: Melanoma-associated antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:33:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:28 2008''
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Revision as of 16:33, 2 May 2008

Image:1i4f.gif

Template:STRUCTURE 1i4f

CRYSTAL STRUCTURE OF HLA-A*0201/MAGE-A4-PEPTIDE COMPLEX


Contents

Overview

The heterotrimeric complex of the human major histocompatibity complex (MHC) molecule HLA-A*0201, beta2-microglobulin and the decameric peptide GVYDGREHTV derived from the melanoma antigen (MAGE-A4 protein has been determined by X-ray crystallography at 1.4 A resolution. MAGE-A4 belongs to a family of genes that are specifically expressed in a variety of tumours. MAGE-A4-derived peptides are presented by MHC molecules at the cell surface to cytotoxic T-lymphocytes. As the HLA-A*0201:MAGE-A4 complex occurs only on tumour cells, it is considered to be an appropriate target for immunotherapy. The structure presented here reveals potential epitopes specific to the complex and indicates which peptide residues could be recognised by T-cell receptors. In addition, as the structure could be refined anisotropically, it was possible to describe the movements of the bound peptide in more detail.

Disease

Known disease associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Stevens-Johnson syndrome, susceptibility to OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700]

About this Structure

1I4F is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene., Hillig RC, Coulie PG, Stroobant V, Saenger W, Ziegler A, Hulsmeyer M, J Mol Biol. 2001 Jul 27;310(5):1167-76. PMID:11502003 Page seeded by OCA on Fri May 2 19:33:38 2008

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OCA

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