7v9e

<StructureSection load='7v9e' size='340' side='right'caption='[[7v9e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[7v9e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V9E FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v9e OCA], [https://pdbe.org/7v9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v9e RCSB], [https://www.ebi.ac.uk/pdbsum/7v9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v9e ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Known ribozymes in contemporary biology perform a limited range of chemical catalysis, but in vitro selection has generated species that catalyze a broader range of chemistry; yet, there have been few structural and mechanistic studies of selected ribozymes. A ribozyme has recently been selected that can catalyze a site-specific methyl transfer reaction. We have solved the crystal structure of this ribozyme at a resolution of 2.3 A, showing how the RNA folds to generate a very specific binding site for the methyl donor substrate. The structure immediately suggests a catalytic mechanism involving a combination of proximity and orientation and nucleobase-mediated general acid catalysis. The mechanism is supported by the pH dependence of the rate of catalysis. A selected methyltransferase ribozyme can thus use a relatively sophisticated catalytic mechanism, broadening the range of known RNA-catalyzed chemistry.

Structure and mechanism of a methyltransferase ribozyme.,Deng J, Wilson TJ, Wang J, Peng X, Li M, Lin X, Liao W, Lilley DMJ, Huang L Nat Chem Biol. 2022 Mar 17. pii: 10.1038/s41589-022-00982-z. doi:, 10.1038/s41589-022-00982-z. PMID:35301479<ref>PMID:35301479</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 7v9e" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Deng, J]]

[[Category: Huang, L]]

[[Category: Lilley, D M.J]]

[[Category: Rna]]