1i51

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[[Image:1i51.gif|left|200px]]
[[Image:1i51.gif|left|200px]]
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{{Structure
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|PDB= 1i51 |SIZE=350|CAPTION= <scene name='initialview01'>1i51</scene>, resolution 2.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1i51", creates the "Structure Box" on the page.
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|SITE=
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|GENE= CASP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), XIAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1i51| PDB=1i51 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i51 OCA], [http://www.ebi.ac.uk/pdbsum/1i51 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i51 RCSB]</span>
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'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''
'''CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP'''
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[[Category: Chai, J.]]
[[Category: Chai, J.]]
[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: caspase]]
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[[Category: Caspase]]
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[[Category: iap]]
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[[Category: Iap]]
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[[Category: protease]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:34:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:14:42 2008''
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Revision as of 16:34, 2 May 2008

Image:1i51.gif

Template:STRUCTURE 1i51

CRYSTAL STRUCTURE OF CASPASE-7 COMPLEXED WITH XIAP


Contents

Overview

The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of caspase-7 in complex with a potent inhibitory fragment from XIAP at 2.45 A resolution. An 18-residue XIAP peptide binds the catalytic groove of caspase-7, making extensive contacts to the residues that are essential for its catalytic activity. Strikingly, despite a reversal of relative orientation, a subset of interactions between caspase-7 and XIAP closely resemble those between caspase-7 and its tetrapeptide inhibitor DEVD-CHO. Our biochemical and structural analyses reveal that the BIR domains are dispensable for the inhibition of caspase-3 and -7. This study provides a structural basis for the design of the next-generation caspase inhibitors.

Disease

Known disease associated with this structure: Lymphoproliferative syndrome, X-linked, 2 OMIM:[300079]

About this Structure

1I51 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of caspase-7 inhibition by XIAP., Chai J, Shiozaki E, Srinivasula SM, Wu Q, Datta P, Alnemri ES, Shi Y, Cell. 2001 Mar 9;104(5):769-80. PMID:11257230 Page seeded by OCA on Fri May 2 19:34:57 2008

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OCA

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