8dja
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of mouse PrP23-144 amyloid fibrils (polymorph 1)== | |
| - | + | <StructureSection load='8dja' size='340' side='right'caption='[[8dja]], [[Resolution|resolution]] 3.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8dja]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DJA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dja OCA], [https://pdbe.org/8dja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dja RCSB], [https://www.ebi.ac.uk/pdbsum/8dja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dja ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Li | + | == Disease == |
| - | [[Category: Surewicz | + | [[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. |
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Li Q]] | ||
| + | [[Category: Surewicz WK]] | ||
Revision as of 16:42, 7 September 2022
Cryo-EM structure of mouse PrP23-144 amyloid fibrils (polymorph 1)
| |||||||||||
