7emt

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<StructureSection load='7emt' size='340' side='right'caption='[[7emt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='7emt' size='340' side='right'caption='[[7emt]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7emt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7emt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EMT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EMT FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MQP:[5,10,15,20-tetraphenylporphyrinato(2-)-kappa~4~N~21~,N~22~,N~23~,N~24~]iron'>MQP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emt OCA], [https://pdbe.org/7emt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emt RCSB], [https://www.ebi.ac.uk/pdbsum/7emt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emt ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7emt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7emt OCA], [https://pdbe.org/7emt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7emt RCSB], [https://www.ebi.ac.uk/pdbsum/7emt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7emt ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[[https://www.uniprot.org/uniprot/G3XD33_PSEAE G3XD33_PSEAE]]
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Tetraphenylporphyrin (TPP) is a symmetrically substituted synthetic porphyrin whose properties can be readily modified, providing it with significant advantages over naturally occurring porphyrins. Herein, we report the first example of a stable complex between a native biomolecule, the haemoprotein HasA, and TPP as well as its derivatives. The X-ray crystal structures of nine different HasA-TPP complexes were solved at high resolutions. HasA capturing TPP derivatives was also demonstrated to inhibit growth of the opportunistic pathogen Pseudomonas aeruginosa. Mutant variants of HasA binding FeTPP were shown to possess a different mode of coordination, permitting the cyclopropanation of styrene.
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Tetraphenylporphyrin Enters the Ring: First Example of a Complex between Highly Bulky Porphyrins and a Protein.,Shisaka Y, Sakakibara E, Suzuki K, Stanfield JK, Onoda H, Ueda G, Hatano M, Sugimoto H, Shoji O Chembiochem. 2022 Jul 19;23(14):e202200095. doi: 10.1002/cbic.202200095. Epub, 2022 Apr 13. PMID:35352458<ref>PMID:35352458</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7emt" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Sakakibara, E]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Shisaka, Y]]
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[[Category: Sakakibara E]]
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[[Category: Shoji, O]]
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[[Category: Shisaka Y]]
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[[Category: Sugimoto, H]]
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[[Category: Shoji O]]
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[[Category: Heme acquisition protein]]
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[[Category: Sugimoto H]]
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[[Category: Transport protein]]
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Revision as of 16:46, 7 September 2022

Crystal Structure of the HasAp V37G Mutant Capturing Iron Tetraphenylporphyrin

PDB ID 7emt

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