7wl4
From Proteopedia
(Difference between revisions)
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==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50== | ==Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50== | ||
| - | <StructureSection load='7wl4' size='340' side='right'caption='[[7wl4]]' scene=''> | + | <StructureSection load='7wl4' size='340' side='right'caption='[[7wl4]], [[Resolution|resolution]] 1.82Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WL4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wl4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WL4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wl4 OCA], [https://pdbe.org/7wl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wl4 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JFU:~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide'>JFU</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wl4 OCA], [https://pdbe.org/7wl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wl4 RCSB], [https://www.ebi.ac.uk/pdbsum/7wl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wl4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li W]] | [[Category: Li W]] | ||
Revision as of 16:50, 7 September 2022
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50
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Categories: Homo sapiens | Large Structures | Li W | Sun L | Wang C | Xu Y | Zhang C | Zhang Y
