4bs6

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<StructureSection load='4bs6' size='340' side='right'caption='[[4bs6]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='4bs6' size='340' side='right'caption='[[4bs6]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bs6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BS6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BS6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bs6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BS6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JG7:(2S,4R)-4-[2-CHLORANYL-4-(4-ETHYLPIPERAZIN-1-YL)PHENYL]SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]-1-[1-(TRIFLUOROMETHYL)CYCLOPROPYL]CARBONYL-PYRROLIDINE-2-CARBOXAMIDE'>JG7</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=JG7:(2S,4R)-4-[2-CHLORANYL-4-(4-ETHYLPIPERAZIN-1-YL)PHENYL]SULFONYL-N-[1-(IMINOMETHYL)CYCLOPROPYL]-1-[1-(TRIFLUOROMETHYL)CYCLOPROPYL]CARBONYL-PYRROLIDINE-2-CARBOXAMIDE'>JG7</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bqv|4bqv]], [[4bs5|4bs5]], [[4bsq|4bsq]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bs6 OCA], [https://pdbe.org/4bs6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bs6 RCSB], [https://www.ebi.ac.uk/pdbsum/4bs6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bs6 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bs6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bs6 OCA], [http://pdbe.org/4bs6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bs6 RCSB], [http://www.ebi.ac.uk/pdbsum/4bs6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bs6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATS_MOUSE CATS_MOUSE]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[[https://www.uniprot.org/uniprot/CATS_MOUSE CATS_MOUSE]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Banner, D W]]
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[[Category: Banner DW]]
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[[Category: Benz, J]]
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[[Category: Benz J]]
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[[Category: Gsell, B]]
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[[Category: Gsell B]]
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[[Category: Haap, W]]
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[[Category: Haap W]]
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[[Category: Ruf, A]]
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[[Category: Ruf A]]
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[[Category: Stihle, M]]
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[[Category: Stihle M]]
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[[Category: Covalent ligand]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase]]
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Revision as of 17:03, 7 September 2022

MOUSE CATHEPSIN S WITH COVALENT LIGAND

PDB ID 4bs6

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