4bsz

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<StructureSection load='4bsz' size='340' side='right'caption='[[4bsz]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
<StructureSection load='4bsz' size='340' side='right'caption='[[4bsz]], [[Resolution|resolution]] 2.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bsz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_w303 Saccharomyces cerevisiae w303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BSZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bsz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_W303 Saccharomyces cerevisiae W303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BSZ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsz OCA], [http://pdbe.org/4bsz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bsz RCSB], [http://www.ebi.ac.uk/pdbsum/4bsz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsz ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bsz OCA], [https://pdbe.org/4bsz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bsz RCSB], [https://www.ebi.ac.uk/pdbsum/4bsz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bsz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/YAR1_YEAST YAR1_YEAST]] Required for normal rate of cell proliferation.
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[[https://www.uniprot.org/uniprot/RS3_YEAST RS3_YEAST]]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic ribosome assembly involves a plethora of factors, which ensure that a correctly folded ribosome contains all ribosomal protein components. Among these assembly factors, Yar1 has recently emerged as a molecular chaperone for ribosomal protein rpS3 of the small ribosomal subunit (40S) in yeast. In complex with its chaperone, rpS3 is imported into the nucleus and protected from aggregation. How rpS3 and other ribosomal proteins are initially sequestered and subsequently integrated into pre-ribosomal particles is currently poorly understood. Here, we present the crystal structure of yeast rpS3 in complex with its chaperone Yar1 at 2.8A resolution. The crystal structure rationalizes how Yar1 can protect rpS3 from aggregation while facilitating nuclear import and suggests a mechanism for a stepwise exchange of molecular partners that ribosomal proteins interact with during ribosome assembly.
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Crystal Structure of the Yeast Ribosomal Protein rpS3 in Complex with Its Chaperone Yar1.,Holzer S, Ban N, Klinge S J Mol Biol. 2013 Sep 7. pii: S0022-2836(13)00542-1. doi:, 10.1016/j.jmb.2013.08.022. PMID:24021814<ref>PMID:24021814</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bsz" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Ribosomal protein S3|Ribosomal protein S3]]
*[[Ribosomal protein S3|Ribosomal protein S3]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae w303]]
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[[Category: Saccharomyces cerevisiae W303]]
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[[Category: Ban, N]]
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[[Category: Ban N]]
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[[Category: Holzer, S]]
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[[Category: Holzer S]]
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[[Category: Klinge, S]]
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[[Category: Klinge S]]
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[[Category: Rna binding protein]]
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Revision as of 17:06, 7 September 2022

Crystal Structure of the Yeast Ribosomal Protein Rps3 in Complex with its Chaperone Yar1

PDB ID 4bsz

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