4btg

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<SX load='4btg' size='340' side='right' viewer='molstar' caption='[[4btg]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
<SX load='4btg' size='340' side='right' viewer='molstar' caption='[[4btg]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4btg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpph6 Bpph6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=4BTG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4btg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_virus_phi6 Pseudomonas virus phi6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTG FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=4btg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btg OCA], [http://pdbe.org/4btg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4btg RCSB], [http://www.ebi.ac.uk/pdbsum/4btg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4btg ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4btg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4btg OCA], [https://pdbe.org/4btg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4btg RCSB], [https://www.ebi.ac.uk/pdbsum/4btg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4btg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/P1_BPPH6 P1_BPPH6]] P1 is the major inner capsid (core) protein of the polyhedral procapsid, which is responsible for genomic replication and transcription. Forms a dodecahedral shell from 60 asymmetric dimers. Binds to RNA and may be involved in genomic packaging.
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[[https://www.uniprot.org/uniprot/P1_BPPH6 P1_BPPH6]] P1 is the major inner capsid (core) protein of the polyhedral procapsid, which is responsible for genomic replication and transcription. Forms a dodecahedral shell from 60 asymmetric dimers. Binds to RNA and may be involved in genomic packaging.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cystovirus varphi6 shares several distinct features with other double-stranded RNA (dsRNA) viruses, including the human pathogen, rotavirus: segmented genomes, nonequivalent packing of 120 subunits in its icosahedral capsid, and capsids as compartments for transcription and replication. varphi6 assembles as a dodecahedral procapsid that undergoes major conformational changes as it matures into the spherical capsid. We determined the crystal structure of the capsid protein, P1, revealing a flattened trapezoid subunit with an alpha-helical fold. We also solved the procapsid with cryo-electron microscopy to comparable resolution. Fitting the crystal structure into the procapsid disclosed substantial conformational differences between the two P1 conformers. Maturation via two intermediate states involves remodeling on a similar scale, besides huge rigid-body rotations. The capsid structure and its stepwise maturation that is coupled to sequential packaging of three RNA segments sets the cystoviruses apart from other dsRNA viruses as a dynamic molecular machine.
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Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid.,Nemecek D, Boura E, Wu W, Cheng N, Plevka P, Qiao J, Mindich L, Heymann JB, Hurley JH, Steven AC Structure. 2013 Aug 6;21(8):1374-83. doi: 10.1016/j.str.2013.06.007. Epub 2013, Jul 25. PMID:23891288<ref>PMID:23891288</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4btg" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
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[[Category: Bpph6]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Boura, E]]
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[[Category: Pseudomonas virus phi6]]
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[[Category: Cheng, N]]
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[[Category: Boura E]]
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[[Category: Heymann, J B]]
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[[Category: Cheng N]]
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[[Category: Hurley, J H]]
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[[Category: Heymann JB]]
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[[Category: Mindich, L]]
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[[Category: Hurley JH]]
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[[Category: Nemecek, D]]
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[[Category: Mindich L]]
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[[Category: Plevka, P]]
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[[Category: Nemecek D]]
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[[Category: Qiao, J]]
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[[Category: Plevka P]]
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[[Category: Steven, A C]]
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[[Category: Qiao J]]
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[[Category: Wu, W]]
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[[Category: Steven AC]]
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[[Category: Cystoviridae]]
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[[Category: Wu W]]
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[[Category: Flexible fitting]]
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[[Category: Procapsid structure]]
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[[Category: Virus]]
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Revision as of 17:06, 7 September 2022

Coordinates of the bacteriophage phi6 capsid subunits (P1A and P1B) fitted into the cryoEM reconstruction of the procapsid at 4.4 A resolution

4btg, resolution 4.40Å

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OCA

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