4bts

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<StructureSection load='4bts' size='340' side='right'caption='[[4bts]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
<StructureSection load='4bts' size='340' side='right'caption='[[4bts]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bts]] is a 144 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila] and [http://en.wikipedia.org/wiki/Tetth Tetth]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpe 4bpe], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpn 4bpn], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpo 4bpo] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpp 4bpp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BTS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bts]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila] and [https://en.wikipedia.org/wiki/Tetrahymena_thermophila_SB210 Tetrahymena thermophila SB210]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpe 4bpe], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpn 4bpn], [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpo 4bpo] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4bpp 4bpp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BTS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bts OCA], [http://pdbe.org/4bts PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bts RCSB], [http://www.ebi.ac.uk/pdbsum/4bts PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bts ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bts OCA], [https://pdbe.org/4bts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bts RCSB], [https://www.ebi.ac.uk/pdbsum/4bts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bts ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I7MK25_TETTS I7MK25_TETTS]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).[RuleBase:RU004365] [[http://www.uniprot.org/uniprot/E6PBR9_TETTH E6PBR9_TETTH]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).[HAMAP-Rule:MF_03015]
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[[https://www.uniprot.org/uniprot/I7MK25_TETTS I7MK25_TETTS]] Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).[RuleBase:RU004365]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Eukaryotic translation initiation factors (eIFs) 1A and 1 are central players in the complex process of start-codon recognition. To improve mechanistic understanding of this process, we determined the crystal structure of the 40S ribosomal subunit in complex with eIF1A and eIF1 from Tetrahymena thermophila at a resolution of 3.7 A. It reveals the positions of the two factors on the 40S and the conformational changes that accompany their binding.
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The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A.,Weisser M, Voigts-Hoffmann F, Rabl J, Leibundgut M, Ban N Nat Struct Mol Biol. 2013 Jul 14. doi: 10.1038/nsmb.2622. PMID:23851459<ref>PMID:23851459</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bts" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Receptor for activated protein kinase C 1|Receptor for activated protein kinase C 1]]
 
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
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*[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]]
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Tetrahymena thermophila]]
[[Category: Tetrahymena thermophila]]
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[[Category: Tetth]]
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[[Category: Tetrahymena thermophila SB210]]
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[[Category: Ban, N]]
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[[Category: Ban N]]
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[[Category: Leibundgut, M]]
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[[Category: Leibundgut M]]
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[[Category: Rabl, J]]
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[[Category: Rabl J]]
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[[Category: Voigts-Hoffmann, F]]
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[[Category: Voigts-Hoffmann F]]
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[[Category: Weisser, M]]
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[[Category: Weisser M]]
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[[Category: Eif1]]
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[[Category: Eif1a]]
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[[Category: Eukaryotic translation initiation]]
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[[Category: Ribosome]]
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[[Category: Small ribosomal subunit]]
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[[Category: Translation]]
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[[Category: Translation initiation]]
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[[Category: Translation initiation factor]]
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Revision as of 17:07, 7 September 2022

THE CRYSTAL STRUCTURE OF THE EUKARYOTIC 40S RIBOSOMAL SUBUNIT IN COMPLEX WITH EIF1 AND EIF1A

PDB ID 4bts

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