4bwa

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<StructureSection load='4bwa' size='340' side='right'caption='[[4bwa]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='4bwa' size='340' side='right'caption='[[4bwa]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4bwa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dsm_2053 Dsm 2053]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BWA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4bwa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BWA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N0B:ADENYLATED+NORBORNENE'>N0B</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N0B:ADENYLATED+NORBORNENE'>N0B</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw9|4bw9]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwa OCA], [https://pdbe.org/4bwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bwa RCSB], [https://www.ebi.ac.uk/pdbsum/4bwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwa ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyrrolysine--tRNA(Pyl)_ligase Pyrrolysine--tRNA(Pyl) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.26 6.1.1.26] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bwa OCA], [http://pdbe.org/4bwa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bwa RCSB], [http://www.ebi.ac.uk/pdbsum/4bwa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bwa ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PYLS_METMA PYLS_METMA]] Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG (By similarity).
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[[https://www.uniprot.org/uniprot/PYLS_METMA PYLS_METMA]] Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Three for two: By using a Methanosarcina mazei PylRS triple mutant (Y306G, Y384F, I405R) the incorporation of two new exo-norbornene-containing pyrrolysine analogues was achieved. X-ray crystallographic analysis led to the identification of the crucial structural elements involved in substrate recognition by the evolved synthetase.
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Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins.,Schneider S, Gattner MJ, Vrabel M, Flugel V, Lopez-Carrillo V, Prill S, Carell T Chembiochem. 2013 Sep 11. doi: 10.1002/cbic.201300435. PMID:24027216<ref>PMID:24027216</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4bwa" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dsm 2053]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Carell, T]]
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[[Category: Methanosarcina mazei]]
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[[Category: Fluegel, V]]
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[[Category: Carell T]]
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[[Category: Gattner, M J]]
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[[Category: Fluegel V]]
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[[Category: Lopez-Carillo, V]]
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[[Category: Gattner MJ]]
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[[Category: Schneider, S]]
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[[Category: Lopez-Carillo V]]
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[[Category: Vrabel, M]]
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[[Category: Schneider S]]
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[[Category: Ligase]]
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[[Category: Vrabel M]]

Revision as of 17:12, 7 September 2022

PylRS Y306G, Y384F, I405R mutant in complex with adenylated norbornene

PDB ID 4bwa

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