4c0j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 3: Line 3:
<StructureSection load='4c0j' size='340' side='right'caption='[[4c0j]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
<StructureSection load='4c0j' size='340' side='right'caption='[[4c0j]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4c0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C0J FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4c0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C0J FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSE:L-HOMOSERINE'>HSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c0k|4c0k]], [[4c0l|4c0l]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0j OCA], [https://pdbe.org/4c0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c0j RCSB], [https://www.ebi.ac.uk/pdbsum/4c0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0j ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c0j OCA], [http://pdbe.org/4c0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c0j RCSB], [http://www.ebi.ac.uk/pdbsum/4c0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c0j ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
+
[[https://www.uniprot.org/uniprot/MIRO_DROME MIRO_DROME]] Mitochondrial GTPase involved in mitochondrial trafficking. Milt and Miro form an essential protein complex that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria. Required for axonal transport to synapses within nerve terminals. Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs).<ref>PMID:16055062</ref> <ref>PMID:16717129</ref>
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
Miro is a highly conserved calcium-binding GTPase at the regulatory nexus of mitochondrial transport and autophagy. Here we present crystal structures comprising the tandem EF hand and carboxy terminal GTPase (cGTPase) domains of Drosophila Miro. The structures reveal two previously unidentified 'hidden' EF hands, each paired with a canonical EF hand. Each EF hand pair is bound to a helix that structurally mimics an EF hand ligand. A key nucleotide-sensing element and a Pink1 phosphorylation site both lie within an extensive EF hand-cGTPase interface. Our results indicate structural mechanisms for calcium, nucleotide and phosphorylation-dependent regulation of mitochondrial function by Miro.
+
-
 
+
-
Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro.,Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE EMBO Rep. 2013 Sep 27. doi: 10.1038/embor.2013.151. PMID:24071720<ref>PMID:24071720</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 4c0j" style="background-color:#fffaf0;"></div>
+
==See Also==
==See Also==
-
*[[Rho GTPase|Rho GTPase]]
+
*[[Rho GTPase 3D structures|Rho GTPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Drome]]
+
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chakravarthy, S]]
+
[[Category: Chakravarthy S]]
-
[[Category: Focia, P J]]
+
[[Category: Focia PJ]]
-
[[Category: Freymann, D M]]
+
[[Category: Freymann DM]]
-
[[Category: Klosowiak, J L]]
+
[[Category: Klosowiak JL]]
-
[[Category: Landahl, E C]]
+
[[Category: Landahl EC]]
-
[[Category: Rice, S E]]
+
[[Category: Rice SE]]
-
[[Category: Wawrzak, Z]]
+
[[Category: Wawrzak Z]]
-
[[Category: Calcium-binding gtpase]]
+
-
[[Category: Hidden ef hand]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Kinesin]]
+
-
[[Category: Mitochondrial transport]]
+
-
[[Category: Mitophagy]]
+

Revision as of 17:19, 7 September 2022

Crystal structure of Drosophila Miro EF hand and cGTPase domains in the apo state (Apo-MiroS)

PDB ID 4c0j

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c0j"
Personal tools