This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

4c2x

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 17:22, 7 September 2022

Human N-myristoyltransferase isoform 2 (NMT2)

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c2x"

@@ Line 3: / Line 3: @@
 <StructureSection load='4c2x' size='340' side='right'caption='[[4c2x]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4c2x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C2X FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4c2x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C2X FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NHW:2-OXOPENTADECYL-COA'>NHW</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c2y|4c2y]], [[4c2z|4c2z]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2x OCA], [https://pdbe.org/4c2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c2x RCSB], [https://www.ebi.ac.uk/pdbsum/4c2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2x ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycylpeptide_N-tetradecanoyltransferase Glycylpeptide N-tetradecanoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.97 2.3.1.97] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c2x OCA], [http://pdbe.org/4c2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4c2x RCSB], [http://www.ebi.ac.uk/pdbsum/4c2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4c2x ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/NMT2_HUMAN NMT2_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
+[[https://www.uniprot.org/uniprot/NMT2_HUMAN NMT2_HUMAN]] Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins.
-<div style="background-color:#fffaf0;">
-== Publication Abstract from PubMed ==
-Protein N-myristoylation is a ubiquitous co- and post-translational modification that has been implicated in the development and progression of a range of human diseases. Here, we report the global N-myristoylated proteome in human cells determined using quantitative chemical proteomics combined with potent and specific human N-myristoyltransferase (NMT) inhibition. Global quantification of N-myristoylation during normal growth or apoptosis allowed the identification of &gt;100 N-myristoylated proteins, &gt;95% of which are identified for the first time at endogenous levels. Furthermore, quantitative dose response for inhibition of N-myristoylation is determined for &gt;70 substrates simultaneously across the proteome. Small-molecule inhibition through a conserved substrate-binding pocket is also demonstrated by solving the crystal structures of inhibitor-bound NMT1 and NMT2. The presented data substantially expand the known repertoire of co- and post-translational N-myristoylation in addition to validating tools for the pharmacological inhibition of NMT in living cells.
-Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.,Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW Nat Commun. 2014 Sep 26;5:4919. doi: 10.1038/ncomms5919. PMID:25255805<ref>PMID:25255805</ref>
-From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-</div>
-<div class="pdbe-citations 4c2x" style="background-color:#fffaf0;"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Glycylpeptide N-tetradecanoyltransferase]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
 [[Category: Large Structures]]
-[[Category: Brannigan, J A]]
+[[Category: Brannigan JA]]
-[[Category: Brassat, U]]
+[[Category: Brassat U]]
-[[Category: Heal, W P]]
+[[Category: Heal WP]]
-[[Category: Mann, D J]]
+[[Category: Mann DJ]]
-[[Category: Serwa, R A]]
+[[Category: Serwa RA]]
-[[Category: Tate, E W]]
+[[Category: Tate EW]]
-[[Category: Thinon, E]]
+[[Category: Thinon E]]
-[[Category: Wilkinson, A J]]
+[[Category: Wilkinson AJ]]
-[[Category: Wright, M H]]
+[[Category: Wright MH]]
-[[Category: Myristoylation]]
-[[Category: Transferase]]

4c2x

From Proteopedia

Revision as of 17:22, 7 September 2022

Human N-myristoyltransferase isoform 2 (NMT2)

Structural highlights

Function

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox