4c3z
From Proteopedia
(Difference between revisions)
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<StructureSection load='4c3z' size='340' side='right'caption='[[4c3z]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='4c3z' size='340' side='right'caption='[[4c3z]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4c3z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4C3Z FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4c3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c3z OCA], [https://pdbe.org/4c3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4c3z RCSB], [https://www.ebi.ac.uk/pdbsum/4c3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4c3z ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/MRP1_HUMAN MRP1_HUMAN]] Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.<ref>PMID:10064732</ref> <ref>PMID:11114332</ref> <ref>PMID:16230346</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baubichon-Cortay | + | [[Category: Baubichon-Cortay H]] |
| - | [[Category: Chaptal | + | [[Category: Chaptal V]] |
| - | [[Category: | + | [[Category: Di Pietro A]] |
| - | + | [[Category: Falson P]] | |
| - | + | [[Category: Gueguen-Chaignon V]] | |
| - | + | [[Category: Magnard S]] | |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
Revision as of 17:25, 7 September 2022
Nucleotide-free crystal structure of nucleotide-binding domain 1 from human MRP1 supports a general-base catalysis mechanism for ATP hydrolysis.
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