1i7w

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[[Image:1i7w.gif|left|200px]]
[[Image:1i7w.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i7w |SIZE=350|CAPTION= <scene name='initialview01'>1i7w</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1i7w", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= CATNB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), CDH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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-->
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|DOMAIN=
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{{STRUCTURE_1i7w| PDB=1i7w | SCENE= }}
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|RELATEDENTRY=[[1i7x|1I7X]], [[2bct|2bct]], [[3bct|3bct]], [[1g3j|1G3J]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i7w OCA], [http://www.ebi.ac.uk/pdbsum/1i7w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i7w RCSB]</span>
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}}
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'''BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX'''
'''BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX'''
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[[Category: Huber, A H.]]
[[Category: Huber, A H.]]
[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
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[[Category: armadillo repeat]]
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[[Category: Armadillo repeat]]
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[[Category: beta-catenin]]
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[[Category: Beta-catenin]]
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[[Category: cell adhesion]]
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[[Category: Cell adhesion]]
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[[Category: e-cadherin]]
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[[Category: E-cadherin]]
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[[Category: extended interface]]
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[[Category: Extended interface]]
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[[Category: phosphoserine]]
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[[Category: Phosphoserine]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:41:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:15:51 2008''
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Revision as of 16:41, 2 May 2008

Image:1i7w.gif

Template:STRUCTURE 1i7w

BETA-CATENIN/PHOSPHORYLATED E-CADHERIN COMPLEX


Overview

As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.

About this Structure

1I7W is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:11348595 Page seeded by OCA on Fri May 2 19:41:04 2008

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OCA

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