4cb9

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<StructureSection load='4cb9' size='340' side='right'caption='[[4cb9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='4cb9' size='340' side='right'caption='[[4cb9]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cb9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cb9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CB9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cb8|4cb8]], [[4cba|4cba]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb9 OCA], [https://pdbe.org/4cb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cb9 RCSB], [https://www.ebi.ac.uk/pdbsum/4cb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cb9 OCA], [http://pdbe.org/4cb9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cb9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cb9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cb9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
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[[https://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CTNNBL1 is a spliceosome-associated protein that binds nuclear localization signals (NLSs) in splice factors CDC5L and Prp31 as well as the antibody diversifying enzyme AID. Here, crystal structures of human CTNNBL1 reveal a distinct structure from its closest homologue karyopherin-alphas. CTNNBL1 comprises a HEAT-like domain (including a nuclear export signal), a central armadillo domain, and a coiled-coil C-terminal domain. Structure-guided mutations of the region homologous to the karyopherin-alpha NLS-binding site fail to disrupt CTNNBL1-NLS interactions. Our results identify CTNNBL1 as a unique selective NLS-binding protein with striking differences from karyopherin-alphas.
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Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha,Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C FEBS Lett. 2013 Nov 20. pii: S0014-5793(13)00847-8. doi:, 10.1016/j.febslet.2013.11.013. PMID:24269683<ref>PMID:24269683</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4cb9" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ganesh, K]]
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[[Category: Ganesh K]]
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[[Category: Johnson, C M]]
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[[Category: Johnson CM]]
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[[Category: Neuberger, M S]]
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[[Category: Neuberger MS]]
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[[Category: Rada, C]]
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[[Category: Rada C]]
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[[Category: Simpson, P]]
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[[Category: Simpson P]]
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[[Category: Telerman, S B]]
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[[Category: Telerman SB]]
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[[Category: Williams, R L]]
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[[Category: Williams RL]]
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[[Category: VanMaldegem, F]]
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[[Category: VanMaldegem F]]
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[[Category: Aid]]
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[[Category: Apoptosis]]
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[[Category: Deaminase]]
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[[Category: Import]]
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Revision as of 17:36, 7 September 2022

Structure of full-length CTNNBL1 in P43212 space group

PDB ID 4cb9

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