4chk

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<StructureSection load='4chk' size='340' side='right'caption='[[4chk]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='4chk' size='340' side='right'caption='[[4chk]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4chk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4chk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chk OCA], [http://pdbe.org/4chk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4chk RCSB], [http://www.ebi.ac.uk/pdbsum/4chk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4chk ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chk OCA], [https://pdbe.org/4chk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chk RCSB], [https://www.ebi.ac.uk/pdbsum/4chk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARFE_ARATH ARFE_ARATH]] Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity.<ref>PMID:12036261</ref> <ref>PMID:14973283</ref> <ref>PMID:17553903</ref>
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[[https://www.uniprot.org/uniprot/ARFE_ARATH ARFE_ARATH]] Auxin response factors (ARFs) are transcriptional factors that binds specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional activator. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Mediates embryo axis formation and vascular tissues differentiation. Functionally redundant with ARF7. May be necessary to counteract AMP1 activity.<ref>PMID:12036261</ref> <ref>PMID:14973283</ref> <ref>PMID:17553903</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The plant hormone auxin is a key morphogenetic regulator acting from embryogenesis onwards. Transcriptional events in response to auxin are mediated by the auxin response factor (ARF) transcription factors and the Aux/IAA (IAA) transcriptional repressors. At low auxin concentrations, IAA repressors associate with ARF proteins and recruit corepressors that prevent auxin-induced gene expression. At higher auxin concentrations, IAAs are degraded and ARFs become free to regulate auxin-responsive genes. The interaction between ARFs and IAAs is thus central to auxin signalling and occurs through the highly conserved domain III/IV present in both types of proteins. Here, we report the crystal structure of ARF5 domain III/IV and reveal the molecular determinants of ARF-IAA interactions. We further provide evidence that ARFs have the potential to oligomerize, a property that could be important for gene regulation in response to auxin.
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Structural basis for oligomerization of auxin transcriptional regulators.,Nanao MH, Vinos-Poyo T, Brunoud G, Thevenon E, Mazzoleni M, Mast D, Laine S, Wang S, Hagen G, Li H, Guilfoyle TJ, Parcy F, Vernoux T, Dumas R Nat Commun. 2014 Apr 7;5:3617. doi: 10.1038/ncomms4617. PMID:24710426<ref>PMID:24710426</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4chk" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arath]]
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brunoud, G]]
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[[Category: Brunoud G]]
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[[Category: Dumas, R]]
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[[Category: Dumas R]]
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[[Category: Mazzoleni, M]]
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[[Category: Mazzoleni M]]
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[[Category: Nanao, M H]]
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[[Category: Nanao MH]]
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[[Category: Parcy, F]]
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[[Category: Parcy F]]
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[[Category: Thevenon, E]]
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[[Category: Thevenon E]]
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[[Category: Vernoux, T]]
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[[Category: Vernoux T]]
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[[Category: Pb1]]
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[[Category: Transcription]]
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Revision as of 17:46, 7 September 2022

Crystal Structure of the ARF5 oligomerization domain

PDB ID 4chk

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