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4chw

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<StructureSection load='4chw' size='340' side='right'caption='[[4chw]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
<StructureSection load='4chw' size='340' side='right'caption='[[4chw]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4chw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_700743 Atcc 700743]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CHW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4chw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CHW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4chv|4chv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4chw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chw OCA], [https://pdbe.org/4chw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4chw RCSB], [https://www.ebi.ac.uk/pdbsum/4chw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4chw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4chw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4chw OCA], [http://pdbe.org/4chw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4chw RCSB], [http://www.ebi.ac.uk/pdbsum/4chw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4chw ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CNGK1_RHILO CNGK1_RHILO]] Cyclic nucleotide-regulated potassium channel activated by cAMP.<ref>PMID:15550244</ref>
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[[https://www.uniprot.org/uniprot/CNGK1_RHILO CNGK1_RHILO]] Cyclic nucleotide-regulated potassium channel activated by cAMP.<ref>PMID:15550244</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyclic nucleotide-modulated ion channels are important for signal transduction and pacemaking in eukaryotes. The molecular determinants of ligand gating in these channels are still unknown, mainly because of a lack of direct structural information. Here we report ligand-induced conformational changes in full-length MloK1, a cyclic nucleotide-modulated potassium channel from the bacterium Mesorhizobium loti, analysed by electron crystallography and atomic force microscopy. Upon cAMP binding, the cyclic nucleotide-binding domains move vertically towards the membrane, and directly contact the S1-S4 voltage sensor domains. This is accompanied by a significant shift and tilt of the voltage sensor domain helices. In both states, the inner pore-lining helices are in an 'open' conformation. We propose a mechanism in which ligand binding can favour pore opening via a direct interaction between the cyclic nucleotide-binding domains and voltage sensors. This offers a simple mechanistic hypothesis for the coupling between ligand gating and voltage sensing in eukaryotic HCN channels.
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Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.,Kowal J, Chami M, Baumgartner P, Arheit M, Chiu PL, Rangl M, Scheuring S, Schroder GF, Nimigean CM, Stahlberg H Nat Commun. 2014 Jan 28;5:3106. doi: 10.1038/ncomms4106. PMID:24469021<ref>PMID:24469021</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4chw" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 700743]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arheit, M]]
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[[Category: Mesorhizobium loti]]
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[[Category: Baumgartner, P]]
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[[Category: Arheit M]]
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[[Category: Chami, M]]
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[[Category: Baumgartner P]]
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[[Category: Chiu, P L]]
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[[Category: Chami M]]
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[[Category: Kowal, J]]
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[[Category: Chiu PL]]
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[[Category: Nimigean, C M]]
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[[Category: Kowal J]]
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[[Category: Rangl, M]]
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[[Category: Nimigean CM]]
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[[Category: Scheuring, S]]
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[[Category: Rangl M]]
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[[Category: Schroeder, G F]]
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[[Category: Scheuring S]]
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[[Category: Stahlberg, H]]
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[[Category: Schroeder GF]]
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[[Category: 2d crystal]]
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[[Category: Stahlberg H]]
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[[Category: Cnbd]]
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[[Category: Transport protein]]
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[[Category: Voltage gated potassium channel]]
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Revision as of 17:46, 7 September 2022

The electron crystallography structure of the cAMP-free potassium channel MloK1

PDB ID 4chw

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