1i8t

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[[Image:1i8t.jpg|left|200px]]
[[Image:1i8t.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1i8t |SIZE=350|CAPTION= <scene name='initialview01'>1i8t</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1i8t", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-galactopyranose_mutase UDP-galactopyranose mutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.9 5.4.99.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1i8t| PDB=1i8t | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i8t OCA], [http://www.ebi.ac.uk/pdbsum/1i8t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i8t RCSB]</span>
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}}
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'''STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI'''
'''STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI'''
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[[Category: Staines, A G.]]
[[Category: Staines, A G.]]
[[Category: Whitfield, C.]]
[[Category: Whitfield, C.]]
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[[Category: contractase]]
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[[Category: Contractase]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: mutase]]
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[[Category: Mutase]]
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[[Category: rossman fold]]
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[[Category: Rossman fold]]
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[[Category: udp-galactopyranose]]
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[[Category: Udp-galactopyranose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:42:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:15 2008''
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Revision as of 16:43, 2 May 2008

Image:1i8t.jpg

Template:STRUCTURE 1i8t

STRCUTURE OF UDP-GALACTOPYRANOSE MUTASE FROM E.COLI


Overview

Uridine diphosphogalactofuranose (UDP-Galf ) is the precursor of the d-galactofuranose (Galf ) residues found in bacterial and parasitic cell walls, including those of many pathogens, such as Mycobacterium tuberculosis and Trypanosoma cruzi. UDP-Galf is made from UDP-galactopyranose (UDP-Galp) by the enzyme UDP-galactopyranose mutase (mutase). The mutase enzyme is essential for the viability of mycobacteria and is not found in humans, making it a viable therapeutic target. The mechanism by which mutase achieves the unprecedented ring contraction of a nonreducing sugar is unclear. We have solved the crystal structure of Escherichia coli mutase to 2.4 A resolution. The novel structure shows that the flavin nucleotide is located in a cleft lined with conserved residues. Site-directed mutagenesis studies indicate that this cleft contains the active site, with the sugar ring of the substrate UDP-galactose adjacent to the exposed isoalloxazine ring of FAD. Assay results establish that the enzyme is active only when flavin is reduced. We conclude that mutase most likely functions by transient reduction of substrate.

About this Structure

1I8T is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

UDP-galactopyranose mutase has a novel structure and mechanism., Sanders DA, Staines AG, McMahon SA, McNeil MR, Whitfield C, Naismith JH, Nat Struct Biol. 2001 Oct;8(10):858-63. PMID:11573090 Page seeded by OCA on Fri May 2 19:42:59 2008

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