7v7c
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex== |
| - | <StructureSection load='7v7c' size='340' side='right'caption='[[7v7c]]' scene=''> | + | <StructureSection load='7v7c' size='340' side='right'caption='[[7v7c]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7v7c]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V7C FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v7c OCA], [https://pdbe.org/7v7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v7c RCSB], [https://www.ebi.ac.uk/pdbsum/7v7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v7c ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v7c OCA], [https://pdbe.org/7v7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v7c RCSB], [https://www.ebi.ac.uk/pdbsum/7v7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v7c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/B2CPZ1_9HIV1 B2CPZ1_9HIV1]] During virus entry, plays a role in the transport of the viral pre-integration (PIC) complex to the host nucleus. This function is crucial for viral infection of non-dividing macrophages. May act directly at the nuclear pore complex, by binding nucleoporins phenylalanine-glycine (FG)-repeat regions.[HAMAP-Rule:MF_04080][RuleBase:RU364021] During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 E3 ligase complex by direct interaction with host VPRPB/DCAF-1. Cell cycle arrest reportedly occurs within hours of infection and is not blocked by antiviral agents, suggesting that it is initiated by the VPR carried into the virion. Additionally, VPR induces apoptosis in a cell cycle dependent manner suggesting that these two effects are mechanistically linked. Detected in the serum and cerebrospinal fluid of AIDS patient, VPR may also induce cell death to bystander cells.[HAMAP-Rule:MF_04080][RuleBase:RU364021] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Liu Q]] |
| + | [[Category: Wang D]] | ||
| + | [[Category: Xiang Y]] | ||
| + | [[Category: Xu J]] | ||
Revision as of 19:28, 7 September 2022
CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex
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