7wso
From Proteopedia
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| - | ==== | + | ==Structure of a membrane protein G== |
| - | <StructureSection load='7wso' size='340' side='right'caption='[[7wso]]' scene=''> | + | <StructureSection load='7wso' size='340' side='right'caption='[[7wso]], [[Resolution|resolution]] 3.03Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7wso]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WSO FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wso OCA], [https://pdbe.org/7wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wso RCSB], [https://www.ebi.ac.uk/pdbsum/7wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wso ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wso OCA], [https://pdbe.org/7wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wso RCSB], [https://www.ebi.ac.uk/pdbsum/7wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wso ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/A0A0A0MS08_HUMAN A0A0A0MS08_HUMAN]] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The B cell receptor (BCR) complex plays a critical role in B cell development and immune responses. The assembly mechanisms underlying the BCR complex remain unknown. We determined the cryo-electron microscopy (cryo-EM) structures of human IgG-BCR and IgM-BCR, which consist of membrane-bound immunoglobulin molecules (mIg) and Igalpha/beta subunits at a 1:1 stoichiometry. Assembly of both BCR complexes involves their extracellular domains, membrane-proximal connection peptides, and transmembrane (TM) helices. The TM helices of mIgG and mIgM share a conserved set of hydrophobic and polar interactions with Igalpha/beta TM helices. By contrast, the IgG-Cgamma3 and IgM-Cmu4 domains interact with extracellular Ig-like domains of Igalpha/beta through head-to-tail and side-by-side modes, respectively. This work reveals the structural basis for BCR assembly and provides insights into BCR triggering. | ||
| + | |||
| + | Cryo-EM structures of two human B cell receptor isotypes.,Ma X, Zhu Y, Dong, Chen Y, Wang S, Yang D, Ma Z, Zhang A, Zhang F, Guo C, Huang Z Science. 2022 Aug 19;377(6608):880-885. doi: 10.1126/science.abo3828. Epub 2022, Aug 18. PMID:35981028<ref>PMID:35981028</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7wso" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Z | + | [[Category: Chen Y]] |
| + | [[Category: Huang Z]] | ||
| + | [[Category: Ma X]] | ||
| + | [[Category: Zhu Y]] | ||
Current revision
Structure of a membrane protein G
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Categories: Homo sapiens | Large Structures | Chen Y | Huang Z | Ma X | Zhu Y
