7wso

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Current revision (19:31, 7 September 2022) (edit) (undo)
 
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====
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==Structure of a membrane protein G==
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<StructureSection load='7wso' size='340' side='right'caption='[[7wso]]' scene=''>
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<StructureSection load='7wso' size='340' side='right'caption='[[7wso]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wso]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WSO FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wso OCA], [https://pdbe.org/7wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wso RCSB], [https://www.ebi.ac.uk/pdbsum/7wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wso ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wso OCA], [https://pdbe.org/7wso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wso RCSB], [https://www.ebi.ac.uk/pdbsum/7wso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wso ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/A0A0A0MS08_HUMAN A0A0A0MS08_HUMAN]]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The B cell receptor (BCR) complex plays a critical role in B cell development and immune responses. The assembly mechanisms underlying the BCR complex remain unknown. We determined the cryo-electron microscopy (cryo-EM) structures of human IgG-BCR and IgM-BCR, which consist of membrane-bound immunoglobulin molecules (mIg) and Igalpha/beta subunits at a 1:1 stoichiometry. Assembly of both BCR complexes involves their extracellular domains, membrane-proximal connection peptides, and transmembrane (TM) helices. The TM helices of mIgG and mIgM share a conserved set of hydrophobic and polar interactions with Igalpha/beta TM helices. By contrast, the IgG-Cgamma3 and IgM-Cmu4 domains interact with extracellular Ig-like domains of Igalpha/beta through head-to-tail and side-by-side modes, respectively. This work reveals the structural basis for BCR assembly and provides insights into BCR triggering.
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Cryo-EM structures of two human B cell receptor isotypes.,Ma X, Zhu Y, Dong, Chen Y, Wang S, Yang D, Ma Z, Zhang A, Zhang F, Guo C, Huang Z Science. 2022 Aug 19;377(6608):880-885. doi: 10.1126/science.abo3828. Epub 2022, Aug 18. PMID:35981028<ref>PMID:35981028</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7wso" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Chen Y]]
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[[Category: Huang Z]]
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[[Category: Ma X]]
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[[Category: Zhu Y]]

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Structure of a membrane protein G

PDB ID 7wso

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