7z1m

==Structure of yeast RNA Polymerase III Elongation Complex (EC)==

<StructureSection load='7z1m' size='340' side='right'caption='[[7z1m]], [[Resolution|resolution]] 3.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[7z1m]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_W303 Saccharomyces cerevisiae W303]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z1M FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4QM:(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-10,13-DIMETHYL-17-[(2R)-PENTAN-2-YL]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-3,7,12-TRIOL'>4QM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z1m OCA], [https://pdbe.org/7z1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z1m RCSB], [https://www.ebi.ac.uk/pdbsum/7z1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z1m ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/RPC1_YEAST RPC1_YEAST]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).

[[Category: Saccharomyces cerevisiae W303]]

[[Category: Mueller CW]]