7rte
From Proteopedia
(Difference between revisions)
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==X-ray structure of wild type RBPJ-L3MBTL3-DNA complex== | ==X-ray structure of wild type RBPJ-L3MBTL3-DNA complex== | ||
| - | <StructureSection load='7rte' size='340' side='right'caption='[[7rte]]' scene=''> | + | <StructureSection load='7rte' size='340' side='right'caption='[[7rte]], [[Resolution|resolution]] 2.06Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RTE FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rte]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RTE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rte OCA], [https://pdbe.org/7rte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rte RCSB], [https://www.ebi.ac.uk/pdbsum/7rte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rte ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=XYZ:BETA-D-XYLOFURANOSE'>XYZ</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rte OCA], [https://pdbe.org/7rte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rte RCSB], [https://www.ebi.ac.uk/pdbsum/7rte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rte ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SUH_MOUSE SUH_MOUSE]] Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.<ref>PMID:7566092</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Synthetic construct]] | ||
[[Category: Hall DP]] | [[Category: Hall DP]] | ||
[[Category: Kovall RA]] | [[Category: Kovall RA]] | ||
[[Category: Yuan Z]] | [[Category: Yuan Z]] | ||
Revision as of 19:47, 7 September 2022
X-ray structure of wild type RBPJ-L3MBTL3-DNA complex
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