7z5x
From Proteopedia
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<StructureSection load='7z5x' size='340' side='right'caption='[[7z5x]], [[Resolution|resolution]] 2.04Å' scene=''> | <StructureSection load='7z5x' size='340' side='right'caption='[[7z5x]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7z5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z5X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7z5x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z5X FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWJ:(2R)-2-[5-(6-AMINO-5-{(1R)-1-[2-(1,3-DIHYDRO-2H-1,2,3-TRIAZOL-2-YL)-5-FLUOROPHENYL]ETHOXY}PYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]PROPANE-1,2-DIOL'>AWJ</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWJ:(2R)-2-[5-(6-AMINO-5-{(1R)-1-[2-(1,3-DIHYDRO-2H-1,2,3-TRIAZOL-2-YL)-5-FLUOROPHENYL]ETHOXY}PYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]PROPANE-1,2-DIOL'>AWJ</scene></td></tr> | ||
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z5x OCA], [https://pdbe.org/7z5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z5x RCSB], [https://www.ebi.ac.uk/pdbsum/7z5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z5x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z5x OCA], [https://pdbe.org/7z5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z5x RCSB], [https://www.ebi.ac.uk/pdbsum/7z5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z5x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/ROS1_HUMAN ROS1_HUMAN]] Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.<ref>PMID:12661006</ref> | + | [[https://www.uniprot.org/uniprot/ROS1_HUMAN ROS1_HUMAN]] Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells.<ref>PMID:12661006</ref> |
== Function == | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/ROS1_HUMAN ROS1_HUMAN]] Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.<ref>PMID:11094073</ref> <ref>PMID:16885344</ref> | + | [[https://www.uniprot.org/uniprot/ROS1_HUMAN ROS1_HUMAN]] Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.<ref>PMID:11094073</ref> <ref>PMID:16885344</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Hargreaves D]] | |
| - | [[Category: Hargreaves | + | |
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Revision as of 19:53, 7 September 2022
ROS1 with AstraZeneca ligand 2
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