7r27
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7r27' size='340' side='right'caption='[[7r27]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='7r27' size='340' side='right'caption='[[7r27]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7r27]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R27 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7r27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum_subsp._plantarum_NC8 Lactiplantibacillus plantarum subsp. plantarum NC8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R27 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr> | ||
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-alanine--[D-alanyl-carrier_protein]_ligase D-alanine--[D-alanyl-carrier protein] ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.54 6.2.1.54] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r27 OCA], [https://pdbe.org/7r27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r27 RCSB], [https://www.ebi.ac.uk/pdbsum/7r27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r27 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r27 OCA], [https://pdbe.org/7r27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r27 RCSB], [https://www.ebi.ac.uk/pdbsum/7r27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r27 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/A0A151G8K4_LACPN A0A151G8K4_LACPN]] Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.[HAMAP-Rule:MF_00593] | + | [[https://www.uniprot.org/uniprot/A0A151G8K4_LACPN A0A151G8K4_LACPN]] Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.[HAMAP-Rule:MF_00593] |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Lactiplantibacillus plantarum subsp. plantarum NC8]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Grangeasse | + | [[Category: Grangeasse C]] |
| - | [[Category: Nikolopoulos | + | [[Category: Nikolopoulos N]] |
| - | [[Category: Ravaud | + | [[Category: Ravaud S]] |
| - | [[Category: Simorre | + | [[Category: Simorre JP]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 03:12, 8 September 2022
Crystal structure of the L. plantarum D-alanine ligase DltA
| |||||||||||
