This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7rjo
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK== | ==Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK== | ||
| - | <StructureSection load='7rjo' size='340' side='right'caption='[[7rjo]]' scene=''> | + | <StructureSection load='7rjo' size='340' side='right'caption='[[7rjo]], [[Resolution|resolution]] 1.38Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rjo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjo OCA], [https://pdbe.org/7rjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjo RCSB], [https://www.ebi.ac.uk/pdbsum/7rjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjo ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rjo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rjo OCA], [https://pdbe.org/7rjo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rjo RCSB], [https://www.ebi.ac.uk/pdbsum/7rjo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rjo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fedorov E]] | [[Category: Fedorov E]] | ||
[[Category: Ghosh A]] | [[Category: Ghosh A]] | ||
[[Category: Islam K]] | [[Category: Islam K]] | ||
Revision as of 03:13, 8 September 2022
Crystal structure of human Bromodomain containing protein 4 (BRD4) in complex with hnRNPK
| |||||||||||
