1i9k

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[[Image:1i9k.gif|left|200px]]
[[Image:1i9k.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1i9k |SIZE=350|CAPTION= <scene name='initialview01'>1i9k</scene>
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The line below this paragraph, containing "STRUCTURE_1i9k", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1i9k| PDB=1i9k | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i9k OCA], [http://www.ebi.ac.uk/pdbsum/1i9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i9k RCSB]</span>
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}}
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'''THE RNA I-MOTIF'''
'''THE RNA I-MOTIF'''
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==About this Structure==
==About this Structure==
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1I9K is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I9K OCA].
==Reference==
==Reference==
The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491284 11491284]
The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11491284 11491284]
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[[Category: Protein complex]]
 
[[Category: Lerou, J L.]]
[[Category: Lerou, J L.]]
[[Category: Nonin-Lecomte, S.]]
[[Category: Nonin-Lecomte, S.]]
[[Category: Snoussi, K.]]
[[Category: Snoussi, K.]]
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[[Category: i-motif]]
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[[Category: I-motif]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: rna]]
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:44:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:35 2008''
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Revision as of 16:44, 2 May 2008

Image:1i9k.gif

Template:STRUCTURE 1i9k

THE RNA I-MOTIF


Overview

Oligodeoxynucleotides with stretches of cytidine residues associate into a four-stranded structure, the i-motif, in which two head-to-tail, intercalated, parallel-stranded duplexes are held together by hemiprotonated C.C+ pairs. We have investigated the possibility of forming an i-motif structure with C-rich ribonucleic acids. The four C-rich RNAs studied, r(UC5), r(C5), r(C5U) and r(UC3), associate into multiple intercalated structures at acidic pH. r(UC5) forms two i-motif structures that differ by their intercalation topologies. We report on a structural study of the main form and we analyze the small conformational differences found by comparison with the DNA i-motif. The stacking topology of the main structure avoids one of the six 2'-OH/2'-OH repulsive contacts expected in a fully intercalated structure. The C3'-endo pucker of the RNA sugars and the orientation of the intercalated C.C+ pairs result in a modest widening of the narrow grooves at the steps where the hydroxyl groups are in close contact. The free energy of the RNA i-motif, on average -4 kJ mol(-1) per C.C+ pair, is half of the value found in DNA i-motif structures.

About this Structure

Full crystallographic information is available from OCA.

Reference

The RNA i-motif., Snoussi K, Nonin-Lecomte S, Leroy JL, J Mol Biol. 2001 May 25;309(1):139-53. PMID:11491284 Page seeded by OCA on Fri May 2 19:44:33 2008

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