8cxo
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment== | ==Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment== | ||
| - | <StructureSection load='8cxo' size='340' side='right'caption='[[8cxo]]' scene=''> | + | <StructureSection load='8cxo' size='340' side='right'caption='[[8cxo]], [[Resolution|resolution]] 3.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[8cxo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CXO FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxo OCA], [https://pdbe.org/8cxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxo RCSB], [https://www.ebi.ac.uk/pdbsum/8cxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxo ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cxo OCA], [https://pdbe.org/8cxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cxo RCSB], [https://www.ebi.ac.uk/pdbsum/8cxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cxo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SMO_MOUSE SMO_MOUSE]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).[UniProtKB:Q99835]<ref>PMID:25644602</ref> [[https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Pyrococcus abyssi GE5]] | ||
[[Category: Cheng Y]] | [[Category: Cheng Y]] | ||
[[Category: Hoppe N]] | [[Category: Hoppe N]] | ||
Revision as of 03:26, 8 September 2022
Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment
| |||||||||||
