1i9y

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[[Image:1i9y.jpg|left|200px]]
[[Image:1i9y.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1i9y", creates the "Structure Box" on the page.
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{{STRUCTURE_1i9y| PDB=1i9y | SCENE= }}
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|RELATEDENTRY=[[1i9z|1I9Z]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i9y OCA], [http://www.ebi.ac.uk/pdbsum/1i9y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i9y RCSB]</span>
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'''CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN'''
'''CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN'''
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[[Category: Tsujishita, Y.]]
[[Category: Tsujishita, Y.]]
[[Category: York, J D.]]
[[Category: York, J D.]]
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[[Category: inositol 5-phosphatase,]]
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[[Category: Inositol 5-phosphatase]]
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[[Category: ipp5c]]
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[[Category: Ipp5c]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:47 2008''
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Revision as of 16:45, 2 May 2008

Image:1i9y.jpg

Template:STRUCTURE 1i9y

CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN


Overview

Inositol polyphosphate 5-phosphatases are central to intracellular processes ranging from membrane trafficking to Ca(2+) signaling, and defects in this activity result in the human disease Lowe syndrome. The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling those of several Mg(2+)-dependent nucleases. Additional loops mediate specific inositol polyphosphate contacts. The 4-phosphate of inositol (1,4)-bisphosphate is misoriented by 4.6 compared to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphorylation site selectivity of the 5-phosphatases. Based on the structure, a series of mutants are described that exhibit altered substrate specificity providing general determinants for substrate recognition.

About this Structure

1I9Y is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase., Tsujishita Y, Guo S, Stolz LE, York JD, Hurley JH, Cell. 2001 May 4;105(3):379-89. PMID:11348594 Page seeded by OCA on Fri May 2 19:45:17 2008

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