7yat
From Proteopedia
(Difference between revisions)
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<StructureSection load='7yat' size='340' side='right'caption='[[7yat]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='7yat' size='340' side='right'caption='[[7yat]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7yat]] is a 24 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YAT FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7yat]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesocricetus_auratus Mesocricetus auratus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YAT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YAT FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yat OCA], [https://pdbe.org/7yat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yat RCSB], [https://www.ebi.ac.uk/pdbsum/7yat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yat ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7yat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7yat OCA], [https://pdbe.org/7yat PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7yat RCSB], [https://www.ebi.ac.uk/pdbsum/7yat PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7yat ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | + | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. |
== Function == | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref> | + | [[https://www.uniprot.org/uniprot/PRIO_MESAU PRIO_MESAU]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).<ref>PMID:19059915</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Chen | + | [[Category: Mesocricetus auratus]] |
| - | [[Category: Chen | + | [[Category: Chen EH-L]] |
| - | [[Category: Huang | + | [[Category: Chen RP-Y]] |
| - | [[Category: Kao | + | [[Category: Huang JYC]] |
| - | [[Category: Lee | + | [[Category: Kao S-W]] |
| - | [[Category: Wu | + | [[Category: Lee C-H]] |
| - | + | [[Category: Wu K-P]] | |
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Revision as of 04:01, 8 September 2022
CryoEM tetra protofilament structure of the hamster prion 108-144 fibril
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