6zrb
From Proteopedia
(Difference between revisions)
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==Crystal structure of SMYD3 conjugate with piperidine-based covalent inhibitor EM127== | ==Crystal structure of SMYD3 conjugate with piperidine-based covalent inhibitor EM127== | ||
| - | <StructureSection load='6zrb' size='340' side='right'caption='[[6zrb]]' scene=''> | + | <StructureSection load='6zrb' size='340' side='right'caption='[[6zrb]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZRB FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zrb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZRB FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zrb OCA], [https://pdbe.org/6zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zrb RCSB], [https://www.ebi.ac.uk/pdbsum/6zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zrb ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=QON:N-[1-(2-Chloroacetyl)piperidin-4-yl]-5-cyclopropyl-1,2-oxazole-3-carboxamide'>QON</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zrb OCA], [https://pdbe.org/6zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zrb RCSB], [https://www.ebi.ac.uk/pdbsum/6zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zrb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/SMYD3_HUMAN SMYD3_HUMAN]] Histone methyltransferase. Specifically methylates 'Lys-4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.<ref>PMID:15235609</ref> <ref>PMID:22419068</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eriksson D]] | [[Category: Eriksson D]] | ||
[[Category: Talibov VO]] | [[Category: Talibov VO]] | ||
Revision as of 04:03, 8 September 2022
Crystal structure of SMYD3 conjugate with piperidine-based covalent inhibitor EM127
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