1i9z

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[[Image:1i9z.jpg|left|200px]]
[[Image:1i9z.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1i9z |SIZE=350|CAPTION= <scene name='initialview01'>1i9z</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1i9z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=2IP:D-MYO-INOSITOL-1,4-BISPHOSPHATE'>2IP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1i9z| PDB=1i9z | SCENE= }}
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|RELATEDENTRY=[[1i9y|1I9Y]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1i9z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i9z OCA], [http://www.ebi.ac.uk/pdbsum/1i9z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1i9z RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION'''
'''CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION'''
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[[Category: Tsujishita, Y.]]
[[Category: Tsujishita, Y.]]
[[Category: York, J D.]]
[[Category: York, J D.]]
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[[Category: ip2,]]
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[[Category: Ip2]]
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[[Category: ip3]]
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[[Category: Ip3]]
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[[Category: ipp5c]]
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[[Category: Ipp5c]]
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[[Category: spsynaptojanin]]
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[[Category: Spsynaptojanin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:46 2008''
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Revision as of 16:45, 2 May 2008

Image:1i9z.jpg

Template:STRUCTURE 1i9z

CRYSTAL STRUCTURE OF INOSITOL POLYPHOSPHATE 5-PHOSPHATASE DOMAIN (IPP5C) OF SPSYNAPTOJANIN IN COMPLEX WITH INOSITOL (1,4)-BISPHOSPHATE AND CALCIUM ION


Overview

Inositol polyphosphate 5-phosphatases are central to intracellular processes ranging from membrane trafficking to Ca(2+) signaling, and defects in this activity result in the human disease Lowe syndrome. The 1.8 resolution structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin bound to Ca(2+) and inositol (1,4)-bisphosphate reveals a fold and an active site His and Asp pair resembling those of several Mg(2+)-dependent nucleases. Additional loops mediate specific inositol polyphosphate contacts. The 4-phosphate of inositol (1,4)-bisphosphate is misoriented by 4.6 compared to the reactive geometry observed in the apurinic/apyrimidinic endonuclease 1, explaining the dephosphorylation site selectivity of the 5-phosphatases. Based on the structure, a series of mutants are described that exhibit altered substrate specificity providing general determinants for substrate recognition.

About this Structure

1I9Z is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase., Tsujishita Y, Guo S, Stolz LE, York JD, Hurley JH, Cell. 2001 May 4;105(3):379-89. PMID:11348594 Page seeded by OCA on Fri May 2 19:45:24 2008

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