7rj2
From Proteopedia
(Difference between revisions)
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==Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer== | ==Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer== | ||
| - | <StructureSection load='7rj2' size='340' side='right'caption='[[7rj2]]' scene=''> | + | <StructureSection load='7rj2' size='340' side='right'caption='[[7rj2]], [[Resolution|resolution]] 2.32Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJ2 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7rj2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RJ2 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rj2 OCA], [https://pdbe.org/7rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rj2 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=QNG:N-[(1S)-1-(3-{4-chloro-3-[(methylsulfonyl)amino]-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl}-6-[3-methyl-3-(methylsulfonyl)but-1-yn-1-yl]pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl]-2-[(3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl]acetamide'>QNG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rj2 OCA], [https://pdbe.org/7rj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7rj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rj2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/B6DRA0_9HIV1 B6DRA0_9HIV1]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bester SM]] | [[Category: Bester SM]] | ||
[[Category: Kvaratskhelia M]] | [[Category: Kvaratskhelia M]] | ||
Revision as of 04:13, 8 September 2022
Co-crystal structure of lenacapavir bound to Q67H/N74D mutant of disulfide stabilized HIV-1 CA hexamer
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