7v2y

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====
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==cryo-EM structure of yeast THO complex with Sub2==
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<StructureSection load='7v2y' size='340' side='right'caption='[[7v2y]]' scene=''>
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<StructureSection load='7v2y' size='340' side='right'caption='[[7v2y]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7v2y]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7V2Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7V2Y FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v2y OCA], [https://pdbe.org/7v2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v2y RCSB], [https://www.ebi.ac.uk/pdbsum/7v2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v2y ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7v2y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7v2y OCA], [https://pdbe.org/7v2y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7v2y RCSB], [https://www.ebi.ac.uk/pdbsum/7v2y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7v2y ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/HPR1_YEAST HPR1_YEAST]] Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.<ref>PMID:12093753</ref> <ref>PMID:12871933</ref> <ref>PMID:14527416</ref> <ref>PMID:15192704</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Chen C]]
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[[Category: Lei M]]
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[[Category: Tan M]]
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[[Category: Wu J]]
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[[Category: Wu Z]]

Revision as of 04:17, 8 September 2022

cryo-EM structure of yeast THO complex with Sub2

PDB ID 7v2y

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