7z8g
From Proteopedia
(Difference between revisions)
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==Cytoplasmic dynein-1 motor domain== | ==Cytoplasmic dynein-1 motor domain== | ||
| - | <StructureSection load='7z8g' size='340' side='right'caption='[[7z8g]]' scene=''> | + | <StructureSection load='7z8g' size='340' side='right'caption='[[7z8g]], [[Resolution|resolution]] 3.52Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z8G FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7z8g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z8G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z8G FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z8g OCA], [https://pdbe.org/7z8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z8g RCSB], [https://www.ebi.ac.uk/pdbsum/7z8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z8g ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z8g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z8g OCA], [https://pdbe.org/7z8g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z8g RCSB], [https://www.ebi.ac.uk/pdbsum/7z8g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z8g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Carter AP]] | [[Category: Carter AP]] | ||
[[Category: Chaaban S]] | [[Category: Chaaban S]] | ||
Revision as of 04:19, 8 September 2022
Cytoplasmic dynein-1 motor domain
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