1ia8

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[[Image:1ia8.gif|left|200px]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ia8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ia8 OCA], [http://www.ebi.ac.uk/pdbsum/1ia8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ia8 RCSB]</span>
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'''THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1'''
'''THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1'''
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[[Category: Ryan, K.]]
[[Category: Ryan, K.]]
[[Category: Tempczyk-Russell, A.]]
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[[Category: protein kinase]]
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[[Category: Protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:45:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:16:53 2008''
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Revision as of 16:45, 2 May 2008

Image:1ia8.gif

Template:STRUCTURE 1ia8

THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1


Overview

The checkpoint kinase Chk1 is an important mediator of cell cycle arrest following DNA damage. The 1.7 A resolution crystal structures of the human Chk1 kinase domain and its binary complex with an ATP analog has revealed an identical open kinase conformation. The secondary structure and side chain interactions stabilize the activation loop of Chk1 and enable kinase activity without phosphorylation of the catalytic domain. Molecular modeling of the interaction of a Cdc25C peptide with Chk1 has uncovered several conserved residues that are important for substrate selectivity. In addition, we found that the less conserved C-terminal region negatively impacts Chk1 kinase activity.

About this Structure

1IA8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation., Chen P, Luo C, Deng Y, Ryan K, Register J, Margosiak S, Tempczyk-Russell A, Nguyen B, Myers P, Lundgren K, Kan CC, O'Connor PM, Cell. 2000 Mar 17;100(6):681-92. PMID:10761933 Page seeded by OCA on Fri May 2 19:45:54 2008

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