7fcc
From Proteopedia
(Difference between revisions)
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<StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]], [[Resolution|resolution]] 2.14Å' scene=''> | <StructureSection load='7fcc' size='340' side='right'caption='[[7fcc]], [[Resolution|resolution]] 2.14Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7fcc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FCC FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fcc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fcc OCA], [https://pdbe.org/7fcc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fcc RCSB], [https://www.ebi.ac.uk/pdbsum/7fcc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fcc ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref> | + | [[https://www.uniprot.org/uniprot/IL1AP_HUMAN IL1AP_HUMAN]] Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.<ref>PMID:9371760</ref> <ref>PMID:10799889</ref> <ref>PMID:12530978</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Wang | + | [[Category: Wang X]] |
| - | [[Category: Zhou | + | [[Category: Zhou J]] |
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Revision as of 04:52, 8 September 2022
IL-1RAcPb TIR domain
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