7nwu
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Co-crystal structure of UPF3B-RRM-NOPS-L with UPF2-MIF4GIII== |
| - | <StructureSection load='7nwu' size='340' side='right'caption='[[7nwu]]' scene=''> | + | <StructureSection load='7nwu' size='340' side='right'caption='[[7nwu]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7nwu]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NWU FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nwu OCA], [https://pdbe.org/7nwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nwu RCSB], [https://www.ebi.ac.uk/pdbsum/7nwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nwu ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nwu OCA], [https://pdbe.org/7nwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nwu RCSB], [https://www.ebi.ac.uk/pdbsum/7nwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nwu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/REN3B_HUMAN REN3B_HUMAN]] FG syndrome;X-linked intellectual disability with marfanoid habitus;X-linked non-syndromic intellectual disability. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:17704778</ref> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/REN3B_HUMAN REN3B_HUMAN]] Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.<ref>PMID:11163187</ref> <ref>PMID:12718880</ref> <ref>PMID:16209946</ref> <ref>PMID:16601204</ref> <ref>PMID:18066079</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Bufton JC]] |
| + | [[Category: Powers KT]] | ||
| + | [[Category: Schaffitzel C]] | ||
| + | [[Category: Szeto JA]] | ||
Revision as of 04:53, 8 September 2022
Co-crystal structure of UPF3B-RRM-NOPS-L with UPF2-MIF4GIII
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