7phm
From Proteopedia
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==Cryo-EM structure of Mycobacterium tuberculosis encapsulin== | ==Cryo-EM structure of Mycobacterium tuberculosis encapsulin== | ||
| - | <StructureSection load='7phm' size='340' side='right'caption='[[7phm]]' scene=''> | + | <StructureSection load='7phm' size='340' side='right'caption='[[7phm]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PHM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7phm]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PHM FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7phm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7phm OCA], [https://pdbe.org/7phm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7phm RCSB], [https://www.ebi.ac.uk/pdbsum/7phm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7phm ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7phm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7phm OCA], [https://pdbe.org/7phm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7phm RCSB], [https://www.ebi.ac.uk/pdbsum/7phm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7phm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ENCAP_MYCTU ENCAP_MYCTU]] Shell component of a type 1 encapsulin nanocompartment in situ; its cargo protects against oxidative stress at low pH. In situ and in E.coli assembles into proteinaceous shells about 22 nm in diameter with 2.5 nm thick walls (PubMed:34751132, PubMed:24855650). Cargo proteins are targeted to the interior via their C-terminal extensions; empty intact shells can be isolated in E.coli in the absence of cargo protein. There are at least 4 possible cargo proteins, DyP (encoded in the same locus), FolB, BfrB and Rv1762c; DyP and Rv1762c have been identified in vivo (PubMed:24855650). Probably involved in protection against oxidative damage from the host immune response (Probable) (PubMed:34751132). A T-cell antigen found in bacterial culture cell filtrates, stimulates mouse immune response. Does not have detectable bacteriocin activity (PubMed:9596740).<ref>PMID:24855650</ref> <ref>PMID:34751132</ref> <ref>PMID:9596740</ref> <ref>PMID:24855650</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
[[Category: Woodward JD]] | [[Category: Woodward JD]] | ||
Revision as of 04:56, 8 September 2022
Cryo-EM structure of Mycobacterium tuberculosis encapsulin
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