7td6

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==aRML prion fibril==
==aRML prion fibril==
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<StructureSection load='7td6' size='340' side='right'caption='[[7td6]]' scene=''>
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<StructureSection load='7td6' size='340' side='right'caption='[[7td6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TD6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7td6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TD6 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7td6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7td6 OCA], [https://pdbe.org/7td6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7td6 RCSB], [https://www.ebi.ac.uk/pdbsum/7td6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7td6 ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7td6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7td6 OCA], [https://pdbe.org/7td6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7td6 RCSB], [https://www.ebi.ac.uk/pdbsum/7td6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7td6 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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== Function ==
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[[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE]] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Mus musculus]]
[[Category: Artikis E]]
[[Category: Artikis E]]
[[Category: Caughey B]]
[[Category: Caughey B]]

Revision as of 04:59, 8 September 2022

aRML prion fibril

PDB ID 7td6

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