7u9g

==Rabies virus glycoprotein pre-fusion trimer in complex with neutralizing antibody RVA122==

<StructureSection load='7u9g' size='340' side='right'caption='[[7u9g]], [[Resolution|resolution]] 3.39&Aring;' scene=''>

<table><tr><td colspan='2'>[[7u9g]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rabies_virus_strain_Pasteur_vaccin Rabies virus strain Pasteur vaccin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7U9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7U9G FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7u9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7u9g OCA], [https://pdbe.org/7u9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7u9g RCSB], [https://www.ebi.ac.uk/pdbsum/7u9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7u9g ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/GLYCO_RABVP GLYCO_RABVP]] Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).

[[Category: Homo sapiens]]

[[Category: Rabies virus strain Pasteur vaccin]]

[[Category: Zyla D]]