7wok

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==Crystal structure of HSA soaked with cisplatin for one week==
==Crystal structure of HSA soaked with cisplatin for one week==
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<StructureSection load='7wok' size='340' side='right'caption='[[7wok]]' scene=''>
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<StructureSection load='7wok' size='340' side='right'caption='[[7wok]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WOK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7wok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WOK FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wok OCA], [https://pdbe.org/7wok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wok RCSB], [https://www.ebi.ac.uk/pdbsum/7wok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wok ProSAT]</span></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wok OCA], [https://pdbe.org/7wok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wok RCSB], [https://www.ebi.ac.uk/pdbsum/7wok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wok ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
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==See Also==
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*[[Albumin 3D structures|Albumin 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chen SL]]
[[Category: Chen SL]]

Revision as of 05:01, 8 September 2022

Crystal structure of HSA soaked with cisplatin for one week

PDB ID 7wok

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