6zbz
From Proteopedia
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<StructureSection load='6zbz' size='340' side='right'caption='[[6zbz]], [[Resolution|resolution]] 1.60Å' scene=''> | <StructureSection load='6zbz' size='340' side='right'caption='[[6zbz]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6zbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6zbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZBZ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QE5:2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic+acid'>QE5</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QE5:2-[(3,4-dimethylphenyl)sulfonylamino]-5-fluoranyl-benzoic+acid'>QE5</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DKFZp586M1622, DVL3, hCG_40299 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zbz OCA], [https://pdbe.org/6zbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zbz RCSB], [https://www.ebi.ac.uk/pdbsum/6zbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zbz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zbz OCA], [https://pdbe.org/6zbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zbz RCSB], [https://www.ebi.ac.uk/pdbsum/6zbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zbz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN]] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Heinemann | + | [[Category: Heinemann U]] |
| - | [[Category: Oschkinat | + | [[Category: Oschkinat H]] |
| - | [[Category: Roske | + | [[Category: Roske Y]] |
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Revision as of 05:20, 8 September 2022
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
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