6zre

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<StructureSection load='6zre' size='340' side='right'caption='[[6zre]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='6zre' size='340' side='right'caption='[[6zre]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6zre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZRE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6zre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZRE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">oprM, oprK, PA0427 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zre OCA], [https://pdbe.org/6zre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zre RCSB], [https://www.ebi.ac.uk/pdbsum/6zre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zre ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zre OCA], [https://pdbe.org/6zre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zre RCSB], [https://www.ebi.ac.uk/pdbsum/6zre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zre ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/OPRM_PSEAE OPRM_PSEAE]] The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref>
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[[https://www.uniprot.org/uniprot/OPRM_PSEAE OPRM_PSEAE]] The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Pseae]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Broutin, I]]
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[[Category: Broutin I]]
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[[Category: Enguene, Y V.Ntsogo]]
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[[Category: Garnier C]]
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[[Category: Garnier, C]]
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[[Category: Guenard S]]
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[[Category: Guenard, S]]
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[[Category: Lascombe MB]]
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[[Category: Lascombe, M B]]
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[[Category: Llanes C]]
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[[Category: Llanes, C]]
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[[Category: Ma M]]
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[[Category: Ma, M]]
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[[Category: Monlezun L]]
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[[Category: Monlezun, L]]
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[[Category: Ntsogo Enguene YV]]
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[[Category: Phan, G]]
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[[Category: Phan G]]
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[[Category: Plesiat, P]]
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[[Category: Plesiat P]]
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[[Category: Salem, M]]
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[[Category: Salem M]]
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[[Category: Antibiotic resistance]]
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[[Category: Efflux pump]]
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[[Category: Outer-membrane channel]]
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[[Category: Tolc-like]]
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[[Category: Translocase]]
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Revision as of 05:20, 8 September 2022

Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa

PDB ID 6zre

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